Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6412 |
| PDBID: | 8IX3 |
| Chains: | HL_G |
| Organism: | Homo sapiens, Severe acute respiratory syndrome coronavirus 2 |
| Method: | EM |
| Resolution (Å): | 3.98 |
| Reference: | 10.1128/jvi.01137-23 |
| Antibody | |
| Antibody: | 1G11 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 BA.4/5 spike glycoprotein |
| Antigen mutation: | Yes |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8IX3_H|Chain B[auth H]|heavy chain of 1G11|Homo sapiens (9606) EVQLVESGGGLVQPGRSLRLSCAASGFKFDDYAMHWVRQAPGKGLEWVSGTSWNSGTTGYADSVRGRFTISRDNAKKSLYLQMNSLGVEDTAFYYCVKDSNYDSSGYLINNFDYWGQGILVTVSS |
Light Chain: L
Mutation: NULL
| >8IX3_L|Chain A[auth L]|light chain of 1G11|Homo sapiens (9606) DIQLTQSPSFLSASVGDRVTITCRASQGIDKYLAWYQQKPGQAPKVLIYAASTLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQLYTFPVTFGPGTKVDVR |
Antigen
Chain: G
Mutation: G7D/S39F/S41P/S43F/T44A/D73N/R76S/K85N/N108K/L120R/S145N/T146K/E152A/F154V/Q166R/N169Y/Y173H/P195K
| >8IX3_G|Chain C[auth G]|BA.4/5 variant spike protein|Severe acute respiratory syndrome coronavirus 2 (2697049) TNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGVNCYFPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGKKFNFNGLTGTGVLTESNK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR32 TYR92 THR93 PHE94 H: ASP31 TYR32 TRP53 ASN54 THR57 SER100 ASN101 TYR102 ASP103 SER104 GLY106 TYR107 LEU108 ILE109 G: THR345 ARG346 LYS440 LEU441 ASP442 SER443 LYS444 VAL445 ASN448 ASN450 TYR451 PRO499 ARG509 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
