Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 641 |
| PDBID: | 3RAJ |
| Chains: | HL_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.04 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | HB7 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | ADP-ribosyl cyclase 1 |
| Antigen mutation: | No |
| Durg Target: | P28907 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3RAJ_H|Chain B[auth H]|heavy chain of the Fab fragment of antibody HB7|Mus musculus (10090) TLVQLKQSGPSLVQPSQRLSITCTVSGFSLISYGVHWVRQSPGKGLEWLGVIWRGGSTDYNAAFMSRLSITKDNSKSQVFFKMNSLQADDTAIYFCAKTLITTGYAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIENR |
Light Chain: L
Mutation: NULL
| >3RAJ_L|Chain C[auth L]|light chain of the Fab fragment of antibody HB7|Mus musculus (10090) IQMTQSSSSFSVSLGDRVTITCKASEDIYNRLAWYQQKPGNAPRLLISGATSLETGVPSRFSGSGSGKDYTLSITSLQTEDVATYYCQQYWSTPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE |
Antigen
Chain: A
Mutation: NULL
| >3RAJ_A|Chain A|ADP-ribosyl cyclase 1|Homo sapiens (9606) EFWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFDTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ILE31 SER32 ARG54 GLY55 ILE101 THR102 THR103 GLY104 TYR105 L: TYR29 ASN30 ARG31 GLY49 TYR90 TRP91 A: ASP202 PRO232 GLU233 VAL235 GLN236 THR237 ASP252 CYS254 GLN255 LYS260 GLU263 SER267 ASN270 GLN272 PHE273 SER274 CYS275 LYS276 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
