Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6399 |
| PDBID: | 8IL3 |
| Chains: | BA_C |
| Organism: | Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.86 |
| Reference: | 10.1186/s13045-022-01395-0 |
| Antibody | |
| Antibody: | FTL004 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human CD38 |
| Antigen mutation: | No |
| Durg Target: | P28907 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >8IL3_B|Chain B|Heavy chain|Homo sapiens (9606) QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNVHWIRQAPGQGLEWIGYFYPRNGATHYNQKFTGRAVLSADTSVSTAYLQISSLKAEDTAVYFCARGETPGTFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKK |
Light Chain: A
Mutation: NULL
| >8IL3_A|Chain A|Light chain|Homo sapiens (9606) DIVLTQSPASLAVSPGQRATITCRASESVDNFGITFMHWYQQKPGQPPKLLIYRASNLESGVPARFSGSGSRTDFTLTINPVEANDTANYYCQQSSKDPRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >8IL3_C|Chain C|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1|Homo sapiens (9606) QQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASN31 PHE32 ILE34 PHE36 ARG54 SER95 SER96 ASP98 ARG100 B: THR30 ASP31 TYR32 ASN33 TYR50 TYR52 ARG54 ASN55 ALA57 THR58 HIS59 GLU100 THR101 PRO102 C: LYS46 GLU49 ILE50 PRO52 GLU53 MET54 ARG55 HIS56 LYS88 LEU89 THR91 GLN92 THR93 ARG172 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
