Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6314 |
| PDBID: | 8GV7 |
| Chains: | CD_B |
| Organism: | Influenza A virus (A/flat-faced bat/Peru/033/2010(H18N11)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1038/s41467-022-35236-y |
| Antibody | |
| Antibody: | PN-SIA28 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus flat-faced bat/Peru/033/2010 H18N11 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >8GV7_C|Chain C|PN-SIA28 heavy chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCAASGFPFSSYGMHWVRQAPGKGLEWVAGVSYDGSYKYYADSVKGRFTISRDSSKSTLYLQMNSLRPEDTAVYYCARPSAIFGIYIILNGLDVWGQGTTVTVSS |
Light Chain: D
Mutation: NULL
| >8GV7_D|Chain D|PN-SIA28 light chain|Homo sapiens (9606) EIVLTQSPSSVSASVGDRVTITCRATQGISSWLAWYQQKPGKPPKLLIFGASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCQQAHSFPLTFGGGTKVEIKR |
Antigen
Chain: B
Mutation: NULL
| >8GV7_B|Chain B|Hemagglutinin H18-HA2|Influenza A virus (A/flat-faced bat/Peru/033/2010(H18N11)) (1395524) GLFGAIAGFIEGGWQGLIDGWYGYHHQNSEGSGYAADKEATQKAVDAITTKVNNIIDKMNTQFESTAKEFNKIEMRIKHLSDRVDDGFLDVWSYNAELLVLLENERTLDFHDANVNNLYQKVKVQLKDNAIDMGNGCFKILHKCNNTCMDDIKNGTYNYYEYRKESHLEKQKIDGV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: SER61 SER82 TYR83 ASP84 TYR87 TYR89 ILE132 PHE133 ILE135 TYR136 ILE137 ILE138 LEU139 D: SER72 SER73 TRP74 ALA133 HIS134 SER135 PHE136 B: GLY16 LEU17 ILE18 ASP19 GLY20 TRP21 HIS26 GLY33 TYR34 ALA35 LYS38 GLU39 THR41 GLN42 VAL45 ASP46 ILE48 THR49 VAL52 ASP150 LYS153 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
