Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6313 |
| PDBID: | 8GV7 |
| Chains: | CD_A |
| Organism: | Influenza A virus (A/flat-faced bat/Peru/033/2010(H18N11)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1038/s41467-022-35236-y |
| Antibody | |
| Antibody: | PN-SIA28 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus flat-faced bat/Peru/033/2010 H18N11 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >8GV7_C|Chain C|PN-SIA28 heavy chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCAASGFPFSSYGMHWVRQAPGKGLEWVAGVSYDGSYKYYADSVKGRFTISRDSSKSTLYLQMNSLRPEDTAVYYCARPSAIFGIYIILNGLDVWGQGTTVTVSS |
Light Chain: D
Mutation: NULL
| >8GV7_D|Chain D|PN-SIA28 light chain|Homo sapiens (9606) EIVLTQSPSSVSASVGDRVTITCRATQGISSWLAWYQQKPGKPPKLLIFGASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCQQAHSFPLTFGGGTKVEIKR |
Antigen
Chain: A
Mutation: NULL
| >8GV7_A|Chain A|Hemagglutinin H18-HA1|Influenza A virus (A/flat-faced bat/Peru/033/2010(H18N11)) (1395524) DQICIGYHSNNSTQTVNTLLESNVPVTSSHSILEKEHNGLLCKLKGKAPLDLIDCSLPAWLMGNPKCDELLTASEWAYIKEDPEPENGICFPGDFDSLEDLILLVSNTDHFRKEKIIDMTRFSDVTTNNVDSACPYDTNGASFYRNLNWVQQNKGKQLIFHYQNSENNPLLIIWGVHQTSNAAEQNTYYGSQTGSTTITIGEETNTYPLVISESSILNGHSDRINYFWGVVNPNQNFSIVSTGNFIWPEYGYFFQKTTNISGIIKSSEKISDCDTICQTKIGAINSTLPFQNIHQNAIGDCPKYVKAQELVLATGLRNNPIKETR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: PHE133 GLY134 ILE135 A: HIS18 ASN20 THR37 SER38 THR322 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
