Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6310 |
| PDBID: | 8GV6 |
| Chains: | GH_D |
| Organism: | Influenza A virus (A/long-tailed duck/Wisconsin/10OS3912/2010(H14N6)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.40 |
| Reference: | 10.1038/s41467-022-35236-y |
| Antibody | |
| Antibody: | PN-SIA28 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus long-tailed duck/Wisconsin/10OS3912/2010 H14N6 hemagglutinin HA2 |
| Antigen mutation: | No |
| Durg Target: | P26137 |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >8GV6_G|Chain G, I|PN-SIA28 heavy chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCAASGFPFSSYGMHWVRQAPGKGLEWVAGVSYDGSYKYYADSVKGRFTISRDSSKSTLYLQMNSLRPEDTAVYYCARPSAIFGIYIILNGLDVWGQGTTVTVSS |
Light Chain: H
Mutation: NULL
| >8GV6_H|Chain H, J|PN-SIA28 light chain|Homo sapiens (9606) EIVLTQSPSSVSASVGDRVTITCRATQGISSWLAWYQQKPGKPPKLLIFGASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCQQAHSFPLTFGGGTKVEIKR |
Antigen
Chain: D
Mutation: NULL
| >8GV6_D|Chain B, D, F|Hemagglutinin H14-HA2|Influenza A virus (A/long-tailed duck/Wisconsin/10OS3912/2010(H14N6)) (1088701) DKQTKGLFGAIAGFIENGWQGLIDGWYGFRHQNAEGTGTAADLKSTQAAIDQINGKLNRLIEKTNEKYHQIEKEFEQVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDVTDSEMNKLFERVRRQLRENAEDQGNGCFEIFHQCDNNCIESIRNGTYDHNIYRDEAINNRIKINPV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: SER61 SER82 TYR83 ASP84 TYR87 ILE132 PHE133 GLY134 ILE135 TYR136 ILE137 ILE138 LEU139 H: SER72 SER73 TRP74 GLY92 SER94 SER95 ALA133 HIS134 SER135 PHE136 D: GLY16 ILE18 ASP19 GLY20 TRP21 THR34 ALA35 LEU38 THR41 GLN42 ILE45 ASP46 ILE48 ASN49 LEU52 ASN53 GLU150 ARG153 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
