Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6309 |
| PDBID: | 8GV6 |
| Chains: | GH_C |
| Organism: | Influenza A virus (A/long-tailed duck/Wisconsin/10OS3912/2010(H14N6)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.40 |
| Reference: | 10.1038/s41467-022-35236-y |
| Antibody | |
| Antibody: | PN-SIA28 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus long-tailed duck/Wisconsin/10OS3912/2010 H14N6 hemagglutinin HA1 |
| Antigen mutation: | No |
| Durg Target: | P26137 |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >8GV6_G|Chain G, I|PN-SIA28 heavy chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCAASGFPFSSYGMHWVRQAPGKGLEWVAGVSYDGSYKYYADSVKGRFTISRDSSKSTLYLQMNSLRPEDTAVYYCARPSAIFGIYIILNGLDVWGQGTTVTVSS |
Light Chain: H
Mutation: NULL
| >8GV6_H|Chain H, J|PN-SIA28 light chain|Homo sapiens (9606) EIVLTQSPSSVSASVGDRVTITCRATQGISSWLAWYQQKPGKPPKLLIFGASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCQQAHSFPLTFGGGTKVEIKR |
Antigen
Chain: C
Mutation: NULL
| >8GV6_C|Chain A, C, E|Hemagglutinin H14-HA1|Influenza A virus (A/long-tailed duck/Wisconsin/10OS3912/2010(H14N6)) (1088701) QITNGNTGNPVICLGHHAVENGTSVKTLTDNHIEVVSAKELVETNHINELCPSPLKLVDGQDCDLINGALGSPGCDHLQDTTWDVFIERPTAMDTCYPFDVPDYQSLRSILASSGSLEFIAEQFTWNGVTVDGSSSACLRGGRNGFFTRLNWLTRVKNGNYGPINVTKENTGSYVRLYLWGVHHPSSDTEQTDLYKVATGRVTVSTRSDQISIIPNIGSRPRVRNQSGRISIYWTLVNPGDSIIFNSIGNLIAPRGHYKINKSTKGTVLKSDKKIGSCTSPCLTDKGSIQSDKPFQNVSRIAIGNCPKYVKQGSLMLATGMRNIP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: PHE133 GLY134 ILE135 C: HIS17 VAL19 VAL36 SER37 THR319 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
