Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6306 |
| PDBID: | 8GSP |
| Chains: | HL_3 |
| Organism: | Foot-and-mouth disease virus A, Bos taurus |
| Method: | EM |
| Resolution (Å): | 3.75 |
| Reference: | 10.1371/journal.ppat.1011811 |
| Antibody | |
| Antibody: | W2 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Foot-and-mouth disease virus (FMDV) A VP3 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8GSP_H|Chain E[auth H]|IG HEAVY CHAIN VARIABLE REGION|Bos taurus (9913) QVQLRESGPSLVKPSQTLSLTCTVSGFSLSRYQVSWVRQAPGKALECLSSISAGGSTGYNPALKSRLSITKDNSKNEVSLSVSTVTPEDTATYYCAKYTDNYDSVNACGFYSGNYYFDAWGQGLLVTVSS |
Light Chain: L
Mutation: NULL
| >8GSP_L|Chain F[auth L]|IG LAMDA CHAIN VARIABLE REGION|Bos taurus (9913) WAQAVLTQPSSVSGSLGQRVSITCSGSSSNVGRGNYVNWFQQIPGSAPRTLIYGATSRASGVPDRFSGSRSGNTATLTISSLQAEDEADYFCATYDSSSNTAVFGSGTTLTVLGDYKDDDDKGG |
Antigen
Chain: 3
Mutation: NULL
| >8GSP_3|Chain C[auth 3]|A/WH/CHA/09 VP3|Foot-and-mouth disease virus A (12111) GIVPVACSDGYGGLVTTDPKTADPAYGMVYNPPRTNYPGRFTNLLDVAEACPTFLCFDDGKPYVVTRADEQRLLAKFDLSLAAKHMSNTYLSGIAQYYAQYSGTINLHFMFTGSTDSKARYMVAYVPPGVTTPPDTPERAAHCIHAEWDTGLNSKFTFSIPYVSAADYAYTASDVADTTNVQGWVCIYQITHGKAEQDTLVVSVSAGKDFELRLPIDPRAQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER30 ARG31 ALA53 GLY54 SER56 ASP100 ASN101 TYR102 ASP103 SER104 VAL105 ASN106 TYR111 SER112 ASN114 TYR115 L: GLY34 TYR36 TYR95 SER97 ASN100 3: ASP58 ASP59 LYS61 ARG67 ALA68 ASP69 GLU70 GLN71 ARG72 LEU73 LYS76 LYS84 HIS85 THR131 THR132 PRO133 ASP135 THR136 ARG139 THR178 THR179 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
