Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6303 |
| PDBID: | 8GSF |
| Chains: | HL_C |
| Organism: | Echovirus E3, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.60 |
| Reference: | 10.3390/v14112322 |
| Antibody | |
| Antibody: | 6D10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Echovirus E3 VP3 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8GSF_H|Chain G[auth E], I[auth H]|Heavy chain of 6D10|Mus musculus (10090) EVQLQQSGPELARPWASVKISCQAFYTFSNYGMQWVKQSPGQGLEWIGPFYPGNADTSYNQKFKGKATLTADKSSSTAYMQFSSLTSEDSAVYYCARVVATTDFDYWGQGTTVTVSS |
Light Chain: L
Mutation: NULL
| >8GSF_L|Chain H[auth F], J[auth L]|Light chain of 6D10|Mus musculus (10090) YIEASQSPSSLAVSVGEKVTMSCKSSQSLLYSSNQKNYLAWFQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVKAEDLAVYYCQQYYSYPYTFGGGTKLKIKR |
Antigen
Chain: C
Mutation: NULL
| >8GSF_C|Chain C[auth 3], F[auth C]|VP3|Echovirus E3 (47516) MLTPGSNQFLTSDDFQSPSAMPQFDVTPEMKIPGEVHNLMEIAEVDSVVPVNNTKENINSMEAYRIPVTGGDQLHTQVFGFQMQPGLNSVFKRTLLGEILNYYAHWSGSVKLTFVFCGSAMATGKFLLAYSPPGASPPQNRKQAMLGTHVIWDVGLQSSCVLCIPWISQTHYRLVQQDEYTSAGYVTCWYQTGLIVPPGAPPSCTILCFASACNDFSVRNLRDTPFIEQTQLLQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN62 L: TYR31 SER32 SER33 C: ASN144 TYR184 THR185 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
