Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6299 |
| PDBID: | 8GSD |
| Chains: | HL_3 |
| Organism: | Mus musculus, Echovirus E3 |
| Method: | EM |
| Resolution (Å): | 3.10 |
| Reference: | 10.3390/v14112322 |
| Antibody | |
| Antibody: | 6D10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Echovirus E3 VP3 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8GSD_H|Chain A[auth H]|Heavy chain of 6D10|Mus musculus (10090) EVQLQQSGPELARPWASVKISCQAFYTFSNYGMQWVKQSPGQGLEWIGPFYPGNADTSYNQKFKGKATLTADKSSSTAYMQFSSLTSEDSAVYYCARVVATTDFDYWGQGTTVTVSS |
Light Chain: L
Mutation: NULL
| >8GSD_L|Chain B[auth L]|Light chain of 6D10|Mus musculus (10090) YIEASQSPSSLAVSVGEKVTMSCKSSQSLLYSSNQKNYLAWFQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVKAEDLAVYYCQQYYSYPYTFGGGTKLKIKR |
Antigen
Chain: 3
Mutation: NULL
| >8GSD_3|Chain E[auth 3]|Genome polyprotein|Echovirus E3 (47516) GLPTMLTPGSNQFLTSDDFQSPSAMPQFDVTPEMKIPGEVHNLMEIAEVDSVVPVNNTKENINSMEAYRIPVTGGDQLHTQVFGFQMQPGLNSVFKRTLLGEILNYYAHWSGSVKLTFVFCGSAMATGKFLLAYSPPGASPPQNRKQAMLGTHVIWDVGLQSSCVLCIPWISQTHYRLVQQDEYTSAGYVTCWYQTGLIVPPGAPPSCTILCFASACNDFSVRMLRDTPFIEQTQLLQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASN31 GLY54 ASN55 L: TYR31 SER32 SER33 ASN34 3: GLN77 HIS79 THR80 SER140 PRO141 GLN143 GLN147 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
