Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6296 |
| PDBID: | 8GRR |
| Chains: | HL_2 |
| Organism: | Foot-and-mouth disease virus A, Bos taurus |
| Method: | EM |
| Resolution (Å): | 3.72 |
| Reference: | 10.1371/journal.ppat.1011811 |
| Antibody | |
| Antibody: | W125 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Foot-and-mouth disease virus (FMDV) A VP2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8GRR_H|Chain E[auth H]|IG HEAVY CHAIN VARIABLE REGION|Bos taurus (9913) QVQLRESGPSLVKPSQTLSLTCTVSGFSLSTYAVYWVRQAPGKALECLGSVSSGDYLTYNPALKSRLTITKDNSKSEVSLSVSTVTPEDTATYYCAKSHSSGYNGWIDFGCYEFTGYGPRYVDAWGQGVQVTVSS |
Light Chain: L
Mutation: NULL
| >8GRR_L|Chain F[auth L]|IG LAMDA CHAIN VARIABLE REGION|Bos taurus (9913) WAQAVLTQPSSVSGSLGQRVSITCSGSSSNVGLGNYVSWFQQIPGSAPRTLIYGATNQASGVPDRFSGSRSGNTATLTISSLQAEDEANYFCASPDSSQTIFGSGTTLTVLGDYKDDDDDKGG |
Antigen
Chain: 2
Mutation: NULL
| >8GRR_2|Chain B[auth 2]|A/WH/CHA/09 VP2|Foot-and-mouth disease virus A (12111) DKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYSTGEDHVSGPNTSGLETRVVQAERFFKKHLFDWTTDKPFGHIEKLELPTDHKGVYGQLVDSFAYMRNGWDVEVSAVGNQFNGGCLLVAMVPEFKEFTTREKYQLTLFPHQFISPRTNMTAHITVPYLGVNRYDQYNKHKPWTLVVMVVSPLTTSSIGASQIKVYTNIAPTHVHVAGELPSKE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR56 LYS64 TYR103 ASN104 GLY105 TRP106 ILE107 ASP108 PHE109 TYR112 GLU113 GLY116 TYR117 ARG120 L: GLY32 LEU33 GLY34 TYR36 ARG70 PRO95 SER98 2: ASP68 THR70 THR71 ASP72 LYS73 PRO74 PHE75 GLY76 HIS77 ILE78 GLU79 LYS80 GLU131 PHE132 THR133 THR134 LYS137 PRO186 LEU187 THR188 THR189 SER195 GLN196 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
