Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6294 |
| PDBID: | 8GQ5 |
| Chains: | n_N |
| Organism: | Homo sapiens, Vicugna pacos |
| Method: | EM |
| Resolution (Å): | 2.70 |
| Reference: | 10.1038/s41467-022-35581-y |
| Antibody | |
| Antibody: | C6 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human sterile alpha (SAM) and Toll/interleukin-1 receptor (TIR) motif containing 1 (SARM1) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: n
Mutation: NULL
| >8GQ5_N|Chain A, AA[auth B], C, CA[auth D], E, EA[auth F], G, I[auth H], K[auth I], M[auth J], O[auth K], Q[auth L], S[auth M], U[auth N], W[auth O], Y[auth P]|NAD(+) hydrolase SARM1|Homo sapiens (9606) MVLTLLLSAYKLCRFFAMSGPRPGAERLAVPGPDGGGGTGPWWAAGGRGPREVSPGAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQVLPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRSSRDSSAGSDTSLEGAAPMGPT |
Antigen
Chain: N
Mutation: NULL
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| n: MET1 VAL3 VAL27 SER30 ARG31 ILE32 TYR33 VAL34 ALA36 TYR38 GLN45 ARG46 GLU47 VAL48 VAL51 ARG53 TYR54 ASN74 ASN97 ASN99 VAL100 GLU101 TRP103 N: LYS375 ARG376 SER379 TYR380 PRO402 ARG403 PRO404 ILE405 LEU406 PRO407 SER408 TRP412 GLU416 THR419 TRP420 GLN422 GLN423 ILE424 GLU469 GLU472 LEU473 PHE476 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
