Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6279 |
| PDBID: | 8GQ1 |
| Chains: | HL_C |
| Organism: | Gallus gallus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.13 |
| Reference: | 10.1002/pro.4745 |
| Antibody | |
| Antibody: | HyHEL10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Gallus gallus lysozyme C |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8GQ1_H|Chain C[auth H]|Heavy Chain of HyHel10 Antibody Fragment (Fab)|Mus musculus (10090) DVQLQESGPSLVKPSQTLSLTCSVTGDSITSDYWSWIRKFPGNRLEYMGYVSYSGSTYYNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYCANWDGDYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGSKPSICGGSHHHHHH |
Light Chain: L
Mutation: NULL
| >8GQ1_L|Chain B[auth L]|Light Chain of HyHel10 Antibody Fragment (Fab)|Mus musculus (10090) DIVLTQSPATLSVTPGNSVSLSCRASQSIGNNLHWYQQKSHESPRLLIKYASQSISGIPSRFRGRGRGTRFRLSINSVETEDFGMYFCQQSNSWPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: C
Mutation: NULL
| >8GQ1_C|Chain A[auth C]|Lysozyme C|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition L: GLY30 ASN31 ASN32 LYS49 TYR50 GLN53 ARG67 SER91 ASN92 SER93 TRP94 TYR96 H: THR330 SER331 ASP332 TYR333 TYR350 SER352 TYR353 SER354 SER356 TYR358 TRP398 ASP399 C: LYS613 ARG614 HIS615 GLY616 ASP618 ASN619 TYR620 ARG621 TRP662 TRP663 ARG673 ASN674 LEU675 CYS676 ASN677 THR689 ASN693 LYS696 LYS697 ILE698 SER700 ASP701 GLY702 ASN703 ALA707 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
