Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 62 |
| PDBID: | 1IGC |
| Chains: | HL_A |
| Organism: | Mus musculus, Streptococcus sp. G148 |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1006/jmbi.1994.1691 |
| Antibody | |
| Antibody: | MOPC21 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | STREPTOCOCCAL PROTEIN G (DOMAIN III) |
| Antigen mutation: | No |
| Durg Target: | P19909; P19909; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1IGC_H|Chain B[auth H]|IGG1-KAPPA MOPC21 FAB (HEAVY CHAIN)|Mus musculus (10090) DVQLVESGGGLVQPGGSRKLSCAASGFTFSSFGMHWVRQAPEKGLEWVAYISSGSSTLHYADTVKGRFTISRDNPKNTLFLQMTSLRSEDTGMYYCARWGNYPYYAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDC |
Light Chain: L
Mutation: NULL
| >1IGC_L|Chain A[auth L]|IGG1-KAPPA MOPC21 FAB (LIGHT CHAIN)|Mus musculus (10090) NIVMTQSPKSMSMSVGERVTLTCKASENVVTYVSWYQQKPEQSPKLLIYGASNRYTGVPDRFTGSGSATDFTLTISSVQAEDLADYHCGQGNSYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >1IGC_A|Chain C[auth A]|STREPTOCOCCAL PROTEIN G (DOMAIN III)|Streptococcus sp. G148 (1324) MTPAVTTYKLVINGKTLKGETTTKAVDAETAEKAFKQYANDNGVDGVWTYDDATKTFTVTE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: GLU123 THR126 SER127 H: LYS122 PRO125 PRO126 SER127 VAL128 TYR129 SER209 SER210 THR211 LYS212 VAL213 ASP214 LYS215 LYS216 VAL218 A: ILE12 LYS15 THR16 LEU17 LYS18 GLY19 GLU20 THR21 THR22 LYS24 TYR38 ASN40 ASP41 ASN42 GLY43 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
