Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6169 |
| PDBID: | 8EZ8 |
| Chains: | HL_A |
| Organism: | Homo sapiens, Influenza A virus (A/Moscow/10/1999(H3N2)) |
| Method: | EM |
| Resolution (Å): | 2.78 |
| Reference: | 10.1016/j.immuni.2023.10.005 |
| Antibody | |
| Antibody: | 3C08 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus Moscow/10/1999 H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P06818 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8EZ8_H|Chain A[auth H]|Heavy chain of influenza virus neuraminidase antibody 3C08|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLTCAISGDSIRNSYWNWIRQPPGRGLEWIGYISNSGSTNYNPSLKGRVSMSLDTSKNQFSLRLNSVTAADTAVYYCSRDKGGLRWGSRGSDVFDIWGQGTMVTVSS |
Light Chain: L
Mutation: NULL
| >8EZ8_L|Chain B[auth L]|Light chain of influenza virus neuraminidase antibody 3C08|Homo sapiens (9606) SVLTQPPSASGTPGQGVTISCSGSTSNIGSNTVNWYQQLPGTAPKLLIYSNDQRPSGVPDRFSGSKSGTSASLAISGLQSDDEADYHCAAWDDSLNGWVFGGGSRLTVL |
Antigen
Chain: A
Mutation: NULL
| >8EZ8_A|Chain C[auth A]|Neuraminidase|Influenza A virus (A/Moscow/10/1999(H3N2)) (480019) AEYRNWSKPQCNITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQFALGQGTTLNNGHSNDTVHDRTPYRTLLMNELGVPFHLGTKQVCIAWSSSSCHDGKAWLHVCVTGDDENATASFIYNGRLVDSIGSWSKKILRTQESECVCINGTCTVVMTDGSASGKADTKILFIEEGKIVHTSPLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPIVDINVKDYSIVSSYVCSGLVGDTPRKNDSSSSSHCLDPNNEEGGHGVKGWAFDDGNDVWMGRTISEKLRSGYETFKVIEGWSKPNSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRKQETEVLWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASN31 SER32 TYR33 TYR50 SER54 GLY55 SER56 THR57 ASN58 LYS96 GLY97 GLY98 LEU99 L: SER30 TYR49 SER50 ASP52 GLN53 TRP91 ASP93 A: HIS264 THR265 SER266 PRO267 LEU268 SER269 GLY270 SER271 ARG283 TYR284 PRO285 GLY286 VAL287 ARG288 ILE302 ASP304 ILE305 ASN306 LYS308 ASP309 TYR310 SER311 ILE312 VAL313 SER314 SER315 CYS318 HIS336 CYS337 LEU338 ASP355 GLY357 ASN358 TRP383 SER384 LYS385 PRO386 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
