Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 616 |
| PDBID: | 3P30 |
| Chains: | HL_A |
| Organism: | Human immunodeficiency virus 1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.30 |
| Reference: | 10.1038/nsmb.1950 |
| Antibody | |
| Antibody: | 1281 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 gp41 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3P30_H|Chain C[auth H]|1281 Fab heavy chain|Homo sapiens (9606) ALQLVQSGAEVKKAGSSVRVSCKASGATFSSYSISWVRQAPGQGPQWMGGIVPSSGAAKYAQQFQGRLTITADTSTNTAYLELSSLRYDDTAVYYCTRDRSRVRYFDRESGWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
Light Chain: L
Mutation: NULL
| >3P30_L|Chain B[auth L]|1281 Fab light chain|Homo sapiens (9606) QSVLTQPPSVSGTPGQRVTISCSGSSSNIGNNYVYWYQQLPGTAPKLLIYKNNIRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDDSLSGPYVFGAGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPIKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAP |
Antigen
Chain: A
Mutation: NULL
| >3P30_A|Chain A|HIV-1 gp41|Human immunodeficiency virus 1 (11676) SITLTVQVRKLLSGIVQQQSNLLRAIEAQQHLLKLTVWGIKQLQARVLSGGRGGWLQWDKEISNYTHIIYELIEESQKQQEKNEQELLELDKWANL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR49 LYS50 ASN51 ASN52 ILE53 ARG54 PRO55 SER56 H: ALA1 LEU2 GLY26 ALA27 THR28 SER30 TYR32 ARG94 ARG96 ARG98 ASP101 A: SER636 THR639 HIS640 TYR643 GLU644 ILE646 GLU647 GLU648 GLN650 LYS651 GLN653 GLU654 LYS655 GLU657 GLN658 LEU661 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
