Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6156 |
| PDBID: | 8EUQ |
| Chains: | IH_F |
| Organism: | Homo sapiens, Influenza A virus |
| Method: | XRD |
| Resolution (Å): | 3.09 |
| Reference: | 10.1016/j.celrep.2023.112391 |
| Antibody | |
| Antibody: | c44H10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human HLA class II histocompatibility antigen, DR alpha chain |
| Antigen mutation: | No |
| Durg Target: | P01903 |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >8EUQ_I|Chain F[auth C], H[auth I]|c44H10 Fab heavy chain|Homo sapiens (9606) QVQLKESGPGLVAPSQSLSITCTVSGFSLTSYGVHWVRQPPGKGLEWLGVIWAGGSINYNSALMSRLSISKDNFKSQVFLKMSSLQTDDTAMYYCARAYGDYVHYAMDYWGQGTSVTASSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: H
Mutation: NULL
| >8EUQ_H|Chain B[auth D], D[auth H]|c44H10 Fab light chain|Homo sapiens (9606) DIQMTQSPSSLSASLGQRVSLTCRASQEISGYLTWLQQKPDGTIKRLVYAASTLDSGVPKRFSGSRSGSDYSLTISSLESEDFADYYCLQYTNYPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: F
Mutation: NULL
| >8EUQ_F|Chain A, C[auth F]|HLA class II histocompatibility antigen, DR alpha chain|Homo sapiens (9606) EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDTSGENLYFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER30 GLY31 TYR32 TYR49 ALA50 ALA51 THR53 LEU54 LYS60 ARG66 SER67 GLY68 I: GLY26 PHE27 SER28 THR30 SER31 TYR32 ARG94 TYR96 GLY97 ASP98 TYR99 F: SER77 ASN78 THR80 PRO81 ILE82 THR83 ASN84 VAL85 PRO86 PRO87 GLU88 VAL89 THR90 LYS111 ASP142 HIS143 LEU144 TRP168 GLY169 LEU170 ASP171 LEU174 LYS176 GLU185 LEU187 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
