Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6151 |
| PDBID: | 8EQ6 |
| Chains: | HL_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.65 |
| Reference: | 10.1016/j.immuni.2024.01.007 |
| Antibody | |
| Antibody: | 19 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human programmed cell death protein 1 (PD-1) |
| Antigen mutation: | No |
| Durg Target: | Q15116 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8EQ6_H|Chain C[auth H]|Antibody FAB heavy chain|Mus musculus (10090) QVQLVQSGAEVKKPGASVKVSCKAFGYTFTTYPIEWMRQAPGKGLEWIGNFHPYNDDTKYNEKFQGRVTLTVDKSSTTVYMELSSLRSEDTAVYYCARENYGSHGGFVYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH |
Light Chain: L
Mutation: NULL
| >8EQ6_L|Chain B[auth L]|Antibody FAB light chain|Mus musculus (10090) ENQLTQSPSSLSASVGDRVTITCRASSSVISSYLHWYQQKPGKAPKLLIYSTSNLASGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYNSYPLTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >8EQ6_A|Chain A|Programmed cell death protein 1|Homo sapiens (9606) GPSGALDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDSRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN1 GLN3 VAL5 GLN6 SER7 GLY8 SER21 PHE25 GLN112 A: PRO15 THR17 SER19 ARG85 LEU119 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
