Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6115 |
| PDBID: | 8EED |
| Chains: | HL_A |
| Organism: | Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013, Macaca mulatta |
| Method: | XRD |
| Resolution (Å): | 3.49 |
| Reference: | 10.1016/j.celrep.2023.112942 |
| Antibody | |
| Antibody: | rhMZ107-B Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | ZIKV virus envelope glycoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8EED_H|Chain E, F[auth H], H[auth I], K[auth M]|rhMZ107-B antibody heavy chain|Macaca mulatta (9544) QVQLQESGPGLVKPSETLSLTCAVSGYSISSGYYWGWIRQPPGKGLEYIGYISGSSGSTYYNPSLKSRVTISKDTSKNQFSLKLSSVTAADTAVYYCARRDRVGSYPYYYGLDSWGQGVLVTVSSASTKGPSVFPLAPSSRSTSESTAALGCLVKDYFPEPVTVSWNSGSLTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYVCNVNHKPSNTKVDKRVEIK |
Light Chain: L
Mutation: NULL
| >8EED_L|Chain G[auth F], I[auth J], J[auth L], L[auth N]|rhMZ107-B antibody light chain|Macaca mulatta (9544) QSVLTQPPSLSASPGASARLPCTLSSDLSVGSKNMYWYQQKPGSAPRLFLYYYSDSDKQLGPGVPNRVSGSKETSSNTAFLLISGLQPEDEADYYCQVYDGSANDVFGSGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVEVAWKADGSAVNAGVETTKPSKQSNNKYAASSYLSLTSDQWKSHKSYSCQVTHEGSTVEKTVAPAE |
Antigen
Chain: A
Mutation: NULL
| >8EED_A|Chain A, B, C, D|Envelope protein E|Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 (2043570) IRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPTVDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFACSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHETDENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER31 TYR33 TYR34 SER53 SER55 SER56 SER58 TYR60 ASP101 ARG102 VAL103 GLY104 SER105 TYR106 PRO107 TYR108 TYR110 L: SER32 LYS33 ASN34 TYR53 SER54 SER56 ASP57 LYS58 GLN59 ASP100 GLY101 SER102 ALA103 A: SER66 ASP67 MET68 ALA69 SER70 ASP71 SER72 ARG73 CYS74 PRO75 THR76 GLN77 ASP83 LYS84 VAL97 ASP98 ARG99 GLY102 ASN103 GLY104 CYS105 GLY106 LEU107 LEU113 THR115 LYS251 ARG252 GLN253 VAL255 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
