Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6072 |
| PDBID: | 8DWY |
| Chains: | ZY_O |
| Organism: | Chikungunya virus strain Senegal 37997, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.18 |
| Reference: | 10.1126/scitranslmed.ade8273 |
| Antibody | |
| Antibody: | CHK-265 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Chikungunya virus (CHIKV) -like particle E2 glycoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: Z
Mutation: NULL
| >8DWY_Z|Chain M[auth H], O[auth V], Q[auth X], S[auth Z]|CHK-265 heavy chain|Homo sapiens (9606) QIQLVQSGREVKNPGETVKISCKASGYTFTEYPMLWVKQAPGKGFRWMGLIYTNTGEPTYAEEFKGRFVFSLEISASTAYLQINNLTNEDTATYFCVRDYFISLDYWGQGTTLTVSS |
Light Chain: Y
Mutation: NULL
| >8DWY_Y|Chain N[auth L], P[auth U], R[auth W], T[auth Y]|CHK-265 light chain|Homo sapiens (9606) QAVVTQESALTTSPGETVTLTCRSNIGAVTSSNCANWVQEKPDHFFTGLIGDTNNRRSGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYNNLWVFGGGTKLTVL |
Antigen
Chain: O
Mutation: NULL
| >8DWY_O|Chain E[auth M], F[auth N], G[auth O], H[auth P]|E2 glycoprotein|Chikungunya virus strain Senegal 37997 (371095) NFNVYKATRPYLAHCPDCGEGHSCHSPIALERIRNEATDGTLKIQVSLQIGIKTDDSHDWTKLRYMDSHTPADAERAGLLVRTSAPCTITGTMGHFILARCPKGETLTVGFTDSRKISHTCTHPFHHEPPVIGRERFHSRPQHGKELPCSTYVQSTAATAEEIEVHMPPDTPDRTLMTQQSGNVKITVNGQTVRYKCNCGGSNEGLTTTDKVINNCKIDQCHAAVTNHKNWQYNSPLVPRNAELGDRKGKIHIPFPLANVTCRVPKARNPTVTYGKNQVTMLLYPDHPTLLSYRNMGQEPNYHEEWVTHKKEVTLTVPTEGLEVTWGNNEPYKYWPQMSTNGTAHGHPHEIILYYYELYPTMTVVIVSVASFVLLSMVGTAVGMCVCARRRCITPYELTPGATVPFLLSLLCCVRTTKA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Z: THR30 GLU31 TYR32 PRO33 LEU35 LEU50 TYR52 THR53 ASN54 THR55 GLU57 THR59 ASP99 PHE101 ILE102 Y: SER32 CYS34 TRP93 TRP98 O: GLN183 GLN184 SER185 GLY186 ASN187 LYS189 CYS203 GLY204 VAL216 ASN218 ASN219 CYS220 LYS221 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
