Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6068 |
| PDBID: | 8DWX |
| Chains: | ZY_O |
| Organism: | Chikungunya virus strain Senegal 37997, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.27 |
| Reference: | 10.1126/scitranslmed.ade8273 |
| Antibody | |
| Antibody: | 506.C01 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Chikungunya virus (CHIKV) -like particle E2 glycoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: Z
Mutation: NULL
| >8DWX_Z|Chain N[auth H], O[auth V], Q[auth X], S[auth Z]|506.C01 heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSQTLSLTCTVSGGSISSDDYYWTWIRLPPGKGLEWIGYIFYTGGTYYNPSLKSRVTISLDRSKNQFSLKLSSVTAADTAVYFCARAPETYCSTTNCYKGYFDSWGQGTLVTVSS |
Light Chain: Y
Mutation: NULL
| >8DWX_Y|Chain M[auth L], P[auth U], R[auth W], T[auth Y]|506.C01 light chain|Homo sapiens (9606) DIQMTQSPSSVSASVGDRVTITCRASQGISSWLGWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPRTFGQGTKVEIK |
Antigen
Chain: O
Mutation: NULL
| >8DWX_O|Chain E[auth M], F[auth N], G[auth O], H[auth P]|E2 glycoprotein|Chikungunya virus strain Senegal 37997 (371095) NFNVYKATRPYLAHCPDCGEGHSCHSPIALERIRNEATDGTLKIQVSLQIGIKTDDSHDWTKLRYMDSHTPADAERAGLLVRTSAPCTITGTMGHFILARCPKGETLTVGFTDSRKISHTCTHPFHHEPPVIGRERFHSRPQHGKELPCSTYVQSTAATAEEIEVHMPPDTPDRTLMTQQSGNVKITVNGQTVRYKCNCGGSNEGLTTTDKVINNCKIDQCHAAVTNHKNWQYNSPLVPRNAELGDRKGKIHIPFPLANVTCRVPKARNPTVTYGKNQVTMLLYPDHPTLLSYRNMGQEPNYHEEWVTHKKEVTLTVPTEGLEVTWGNNEPYKYWPQMSTNGTAHGHPHEIILYYYELYPTMTVVIVSVASFVLLSMVGTAVGMCVCARRRCITPYELTPGATVPFLLSLLCCVRTTKA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Z: ASP32 ASP33 TYR35 TYR52 PHE54 THR56 GLY58 THR59 TYR60 LYS66 GLU102 THR103 TYR104 CYS105 SER106 LYS112 Y: TRP32 ALA91 ASN92 SER93 PHE94 O: GLN184 SER185 GLY186 ASN187 LYS189 ASP214 LYS215 VAL216 ASN218 ASN219 CYS220 LYS221 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
