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Entry information

Complex
AACDB_ID: 6066
PDBID: 8DWX
Chains: VU_M
Organism: Chikungunya virus strain Senegal 37997, Homo sapiens
Method: EM
Resolution (Å): 3.27
Reference: 10.1126/scitranslmed.ade8273
Antibody
Antibody: 506.C01 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Chikungunya virus (CHIKV) -like particle E2 glycoprotein
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: V
Mutation: NULL

>8DWX_V|Chain N[auth H], O[auth V], Q[auth X], S[auth Z]|506.C01 heavy chain|Homo sapiens (9606)
QVQLQESGPGLVKPSQTLSLTCTVSGGSISSDDYYWTWIRLPPGKGLEWIGYIFYTGGTYYNPSLKSRVTISLDRSKNQFSLKLSSVTAADTAVYFCARAPETYCSTTNCYKGYFDSWGQGTLVTVSS

Light Chain: U
Mutation: NULL

>8DWX_U|Chain M[auth L], P[auth U], R[auth W], T[auth Y]|506.C01 light chain|Homo sapiens (9606)
DIQMTQSPSSVSASVGDRVTITCRASQGISSWLGWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPRTFGQGTKVEIK

Antigen

Chain: M
Mutation: NULL

>8DWX_M|Chain E[auth M], F[auth N], G[auth O], H[auth P]|E2 glycoprotein|Chikungunya virus strain Senegal 37997 (371095)
NFNVYKATRPYLAHCPDCGEGHSCHSPIALERIRNEATDGTLKIQVSLQIGIKTDDSHDWTKLRYMDSHTPADAERAGLLVRTSAPCTITGTMGHFILARCPKGETLTVGFTDSRKISHTCTHPFHHEPPVIGRERFHSRPQHGKELPCSTYVQSTAATAEEIEVHMPPDTPDRTLMTQQSGNVKITVNGQTVRYKCNCGGSNEGLTTTDKVINNCKIDQCHAAVTNHKNWQYNSPLVPRNAELGDRKGKIHIPFPLANVTCRVPKARNPTVTYGKNQVTMLLYPDHPTLLSYRNMGQEPNYHEEWVTHKKEVTLTVPTEGLEVTWGNNEPYKYWPQMSTNGTAHGHPHEIILYYYELYPTMTVVIVSVASFVLLSMVGTAVGMCVCARRRCITPYELTPGATVPFLLSLLCCVRTTKA

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

V: ASP32 ASP33 TYR35 TYR52 PHE54 THR56 GLY58 THR59 TYR60 LYS66 GLU102 THR103 TYR104 CYS105 SER106 LYS112

U: TRP32 ALA91 ASN92 SER93 PHE94 ARG96

M: GLN184 SER185 GLY186 ASN187 LYS189 ASP214 LYS215 VAL216 ASN218 ASN219 CYS220 LYS221

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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