Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6062 |
| PDBID: | 8DWW |
| Chains: | VU_M |
| Organism: | Chikungunya virus strain Senegal 37997, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.13 |
| Reference: | 10.1126/scitranslmed.ade8273 |
| Antibody | |
| Antibody: | 506.A08 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Chikungunya virus (CHIKV) -like particle E2 glycoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: V
Mutation: NULL
| >8DWW_V|Chain B[auth H], G[auth V], L[auth X], Q[auth Z]|506.A08 heavy chain|Homo sapiens (9606) EEQLVESGGGLVQPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSYISSSSSTIHYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGNSGYEPLDYWGQGTLVTVS |
Light Chain: U
Mutation: NULL
| >8DWW_U|Chain C[auth L], H[auth U], M[auth W], R[auth Y]|506.A08 light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPWTFGQGTKVEI |
Antigen
Chain: M
Mutation: NULL
| >8DWW_M|Chain D[auth M], I[auth N], N[auth O], S[auth P]|E2 glycoprotein|Chikungunya virus strain Senegal 37997 (371095) NFNVYKATRPYLAHCPDCGEGHSCHSPIALERIRNEATDGTLKIQVSLQIGIKTDDSHDWTKLRYMDSHTPADAERAGLLVRTSAPCTITGTMGHFILARCPKGETLTVGFTDSRKISHTCTHPFHHEPPVIGRERFHSRPQHGKELPCSTYVQSTAATAEEIEVHMPPDTPDRTLMTQQSGNVKITVNGQTVRYKCNCGGSNEGLTTTDKVINNCKIDQCHAAVTNHKNWQYNSPLVPRNAELGDRKGKIHIPFPLANVTCRVPKARNPTVTYGKNQVTMLLYPDHPTLLSYRNMGQEPNYHEEWVTHKKEVTLTVPTEGLEVTWGNNEPYKYWPQMSTNGTAHGHPHEIILYYYELYPTMTVVIVSVASFVLLSMVGTAVGMCVCARRRCITPYELTPGATVPFLLSLLCCVRTTKA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| V: SER31 TYR50 SER52 SER53 SER56 THR57 HIS59 ASN101 SER102 GLY103 TYR104 GLU105 U: TYR32 SER91 TYR92 THR94 TRP96 M: ASN187 LYS189 VAL192 ASN193 GLY194 TYR199 GLY209 THR212 THR213 ASP214 LYS215 VAL216 ASN218 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
