Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6042 |
| PDBID: | 8DUA |
| Chains: | HL_G |
| Organism: | Simian immunodeficiency virus, Macaca mulatta |
| Method: | EM |
| Resolution (Å): | 4.32 |
| Reference: | 10.1038/s41594-022-00852-1 |
| Antibody | |
| Antibody: | ITS92.02 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Simian immunodeficiency viruses E660.CR54 SOS-2P envelope glycoprotein - gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8DUA_H|Chain C[auth D], G[auth H], K[auth J]|ITS92.02 Heavy Chain|Macaca mulatta (9544) QVQLQESGPGLVKPSETLSLTCAVSGGSVSGNWWSWIRQPPGKGLEYIGRISGSDGTTYYRSSLKVTISRDTSKNQFSLRLNSVTAADTAVYYCARKPTWDWFDVWGPGLLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKGLEVLFQ |
Light Chain: L
Mutation: NULL
| >8DUA_L|Chain D[auth E], H[auth K], L|ITS92.02 Light Chain|Macaca mulatta (9544) DIQMTQSPSSLSASVGDRVTITCRASQGIDNYLNWYQQKPGKAPKRLIFAASSLHNGVPSRFSGSGSGTKFTLTISSLQPEDLGTYYCLQYYSDPYTFGQGTKVEIKRTVAAPSVFIFPPSEDQVKSGTVSVVCLLNNFYPREASVKWKVDGALKTGNSQESVTEQDSKDNTYSLSSTLTLSSTEYQSHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: G
Mutation: NULL
| >8DUA_G|Chain B[auth C], F[auth G], J[auth I]|Envelope glycoprotein gp120|Simian immunodeficiency virus (11723) IQYVTVFYGVPAWKNATIPLFCATKNRDTWGTTQCLPDNDDYSELAINITEAFDAWNNTVTEQAIEDVWNLFETSIKPCVKLTPLCIAMRCNKTETDRWGLTRNAGTTTTTTTTTTAATPSVAENVINESNPCIKNNSCAGLEQEPMIGCKFNMTGLKRDKRIEYNETWYSRDLICEQSANESESKCYMHHCNTSVIQESCDKHYWDAIRFRYCAPPGYALLRCNDSNYSGFAPNCSKVVVSSCTRMMETQTSTWFGFNGTRAENRTYIYWHGKSNRTIISLNKYYNLTMRCRRPGNKTVLPVTIMSGLVFHSQPINERPKQAWCWFGGSWKEAIQEVKETLVKHPRYTGTNDTRKINLTAPAGGDPEVTFMWTNCRGEFLYCKMNWFLNWVEDRDQKSSRWRQQNTRERQKKNYVPCHIRQIINTWHKVGKNVYLPPREGDLTCNSTVTSLIAEIDWTNNNETNITMSAEVAELYRLELGDYKLVEITPIGLAPTSCRRYTTTGASRRRRR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TRP98 L: ASP30 ASN31 TYR32 ALA50 SER67 TYR91 G: ILE33 GLN34 TYR35 ARG502 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
