Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6019 |
| PDBID: | 8DPL |
| Chains: | AB_D |
| Organism: | Homo sapiens, Mus musculus, Ebola virus - Mayinga, Zaire, 1976 |
| Method: | EM |
| Resolution (Å): | 2.53 |
| Reference: | 10.1016/j.celrep.2023.113366 |
| Antibody | |
| Antibody: | 2.1.1D5 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Ebola virus Mayinga/Zaire/1976 glycoprotein GP1 |
| Antigen mutation: | No |
| Durg Target: | Q05320 |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >8DPL_A|Chain A, D[auth F], G[auth K]|2.1.1D5 heavy chain variable domain|Homo sapiens (9606) EVQLVESGGGLVKPGGSLRLSCAASGFTFSNAWMNWVRQAPGKGLEWVGRIKSKTDGGAADYAAPVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYFCTTVYRYNYDSVWGQGTLVTVSS |
Light Chain: B
Mutation: NULL
| >8DPL_B|Chain B, E[auth G], H[auth L]|2.1.1D5 light chain variable domain|Homo sapiens (9606) QSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVYWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSFDSSLRDSWVFGGGTKLTVL |
Antigen
Chain: D
Mutation: NULL
| >8DPL_D|Chain J[auth D], L[auth I], N[auth M]|Glycoprotein GP1|Ebola virus - Mayinga, Zaire, 1976 (128952) IPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTVVS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TRP33 ARG50 LYS52 THR55 ASP56 VAL101 TYR104 TYR106 B: SER27 ALA31 GLY32 TYR33 ASP34 TYR36 PHE93 SER95 SER96 ARG98 ASP99 TRP101 D: LYS114 LYS115 PRO116 ASP117 GLY118 SER119 GLY143 THR144 PRO146 CYS147 ALA148 GLN221 THR223 GLY224 THR227 GLU229 GLU231 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
