Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6015 |
| PDBID: | 8DMJ |
| Chains: | DE_C |
| Organism: | Henipavirus nipahense, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.20 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 1H1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Henipavirus nipahense fusion glycoprotein F1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >8DMJ_D|Chain D, F[auth H]|antibody 1H1 heavy chain|Mus musculus (10090) AVQLQQSGAELMRPGASMKISCKATGYTFSSYWIDWVKQRPGHGLEWIGEILPGSGDTNYNENFKGKAAFTADTSSNTAYMQLTSLTSEDSAVFYCARGGRYHGQGFFDYWGQGTTLTVSS |
Light Chain: E
Mutation: NULL
| >8DMJ_E|Chain E, G[auth L]|antibody 1H1 light chain|Mus musculus (10090) AIQMTQSPASLSASVGETVTITCRPSENVHIYLAWYQQKQGKSPQLLVYNAKTLADGVPSRFSGSASGTQFSLKINSLQPEDFGSYYCQHFWSIPYTFGGGTKLEIK |
Antigen
Chain: C
Mutation: NULL
| >8DMJ_C|Chain A, B, C|Fusion glycoprotein F0,Fusion glycoprotein F1|Nipah henipavirus (3052225) MYSMQLASCVTLTLVLLVNSQGILHYEKLSKIGLVKGVTRKYKIKSNPLTKDIVIKMIPNVSNMSQCTGSVMENYKTRLNGILTPIKGALEIYKNGGSGVAIGIATAAQITAGVALYEAMKNADNINKLKSSIESTNEAVVKLQETAEKTVYVLTALQDYINTNLVPTIDKISCKQTELSLDLALSKYLSDLLFVFGPNLQDPVSNSMTIQAISQAFGGNYETLLRTLGYATEDFDDLLESDSITGQIIYVDLSSYYIIVRVYFPILTEIQQAYIQELLPVSFNNDNSEWISIVPNFILVRNTLISNIEIGFCLITKRSVICNQDYATPMTNNMRECLTGSTEKCPRELVVSSHVPRFALSNGVLFANCISVTCQCQTTGRAISQSGEQTLLMIDNTTCPTAVLGNVIISLGKYLGSVNYNSEGIAIGPPVFTDKVDISSQISSMNQSLQQSKDYIKEAQRLLDTVNPSLKLMKQIEDKIEEILSKIYHIENEIARIKKLIGEAPGGLVPRGSHHHHHHSAWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: TRP33 ASP35 GLU50 ASP56 ASN58 GLY96 ARG97 TYR98 HIS99 E: GLU27 HIS30 TYR32 PHE91 TRP92 SER93 ILE94 TYR96 C: GLN393 CYS394 THR396 THR397 GLY398 ARG399 ALA400 ILE401 SER402 GLN403 ASN414 THR415 THR416 CYS417 PRO418 LYS431 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
