Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5992 |
| PDBID: | 8DG9 |
| Chains: | FG_B |
| Organism: | Respiratory syncytial virus A2, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 2.24 |
| Reference: | 10.1038/s41467-023-36459-3 |
| Antibody | |
| Antibody: | MxR Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Respiratory syncytial virus (RSV) A2 fusion glycoprotein F0 |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; |
Sequence information
Antibody
Heavy Chain: F
Mutation: NULL
| >8DG9_F|Chain B[auth D], E[auth F], H|mAb MxR Heavy Chain, VH region|Homo sapiens (9606) EVQVVESGGGLVKPGGSLRLSCAASGFPFSSYKMDWVRQAPGKGLEWVSSISASGSYINYADSVKGRFTISRDNAKNSLYLQMKSLRADDTAVYFCARDGGRELSPFEKWGQGILVTVSS |
Light Chain: G
Mutation: NULL
| >8DG9_G|Chain C[auth E], F[auth G], I[auth L]|mAb MxR Light Chain, VL region|Homo sapiens (9606) QSVLTQPPSVSGAPGQRVTISCTGTNSNIGTGYDVHWYQQLPGTAPKVVLFDNNNRPSGVPDRFSGSKSGTSAALAITGLQAEDEAVYYCQSYDKSLGGWVFGGGTKLTVL |
Antigen
Chain: B
Mutation: NULL
| >8DG9_B|Chain A, D[auth B], G[auth C]|Fusion glycoprotein F0|Respiratory syncytial virus A2 (1972429) MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGLNDIFEAQKIEWHEGSHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: PRO28 SER30 SER31 TYR32 LYS33 ALA52 SER53 SER55 TYR56 ILE57 ASN58 GLY96 GLY97 ARG98 GLU99 G: GLY28 THR29 GLY30 TYR31 TYR91 LYS93 B: GLN26 LEU45 VAL178 SER186 LEU188 ASN262 ASP263 MET264 PRO265 ILE266 THR267 ASN268 ASP269 GLN270 LYS271 LYS272 LEU273 GLY307 VAL308 ILE309 ASP310 THR311 PRO312 ASP344 ALA346 GLY347 ARG364 SER377 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
