Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5963 |
| PDBID: | 8DE3 |
| Chains: | BC_A |
| Organism: | Sus scrofa, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.30 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 15B8 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Sus scrofa transporter |
| Antigen mutation: | No |
| Durg Target: | P31645 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >8DE3_B|Chain B|15B8 Fab heavy chain variable domain|Mus musculus (10090) QVQLQQSGPELVKLGASVRISCKASGYRFSYSWMNWVKQRPGKGLEWIGRIYPGDGDTKYSGKFKGKATLTADKSSSTVYMQLSSLTSEDSAVYFCARSAYGSEGFAMDYWGQGTSVT |
Light Chain: C
Mutation: NULL
| >8DE3_C|Chain C|15B8 Fab light chain variable domain|Mus musculus (10090) DIVLTQSPASLAVSLGQRATISCRASESVDNYGISFLNWFQQKPGQPPKLLIYAASNQGSGVPARFSGSGSGTYFSLNIHPMEEDDTAVYFCQQTKGVSWTFGGGTKVEI |
Antigen
Chain: A
Mutation: NULL
| >8DE3_A|Chain A|Transporter|Sus scrofa (9823) RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGFAICVIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNVTWMLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIILSILLVRGATLPGAWRGVLFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHFWSKRREWLALGVVITCFLGSLITLTFGGAYVVKLLEEFATGPAVLTVALIEAVAVFWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLVFIICSFLMSPPQLWLFQYNYPQWSIILGYCIGTSSFICIPTYITYRLIITPGTLKERIVKGITPETP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ARG47 TYR50 TRP52 TYR71 ASP74 ASP76 LYS78 TYR120 GLY121 SER122 PHE125 C: ASN51 TYR52 GLY53 ILE54 PHE56 GLY117 A: GLN231 SER236 CYS237 LYS238 ASN239 SER240 TRP241 ASN242 THR243 GLY244 ASN245 CYS246 THR247 TYR249 MET258 ARG271 HIS272 GLN275 HIS277 ARG278 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
