Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 596 |
| PDBID: | 3NH7 |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | 10.1371/journal.pone.0013049 |
| Antibody | |
| Antibody: | AbD1556 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Bone morphogenetic protein receptor type-1A |
| Antigen mutation: | No |
| Durg Target: | P36894 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3NH7_H|Chain A[auth H], D[auth I], G[auth J], J[auth K]|Antibody fragment Fab AbD1556, heavy chain|Homo sapiens (9606) QVQLVESGGGLVQPGGSLRLSCAASGFTFSNYTLNWVRQAPGKGLEWVSYTSSSGSLTGYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARERWHVRGYFDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSEFSAWSHPQFEK |
Light Chain: L
Mutation: NULL
| >3NH7_L|Chain B[auth L], E[auth M], H[auth N], K[auth O]|Antibody fragment Fab AbD1556, light chain|Homo sapiens (9606) DIELTQPPSVSVAPGQTARISCSGDSLGSKYVIWYQQKPGQAPVLVIYDDSNRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCSTFTMSGNGTVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEA |
Antigen
Chain: A
Mutation: NULL
| >3NH7_A|Chain C[auth A], F[auth B], I[auth C], L[auth D]|Bone morphogenetic protein receptor type-1A|Homo sapiens (9606) QNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN1 VAL2 GLY26 PHE27 THR28 SER30 ASN31 TYR32 THR33 ASN35 TYR50 SER52 SER53 LEU57 ARG98 GLU99 ARG100 TRP101 HIS102 VAL103 ARG104 TYR106 L: GLY28 SER29 LYS30 TYR31 ASP50 SER51 ASN52 ARG53 ASN65 PHE90 MET92 ASN95 GLY96 THR97 A: HIS43 PHE60 ILE62 GLU64 GLU65 ASP66 ASP67 GLN68 ALA74 CYS77 MET78 LYS79 TYR80 GLU81 GLY82 ASP84 GLN86 SER90 PRO91 LYS92 ALA93 GLN94 LEU95 ARG96 ARG97 ILE99 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
