Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5958 |
| PDBID: | 8DBZ |
| Chains: | DE_A |
| Organism: | Orthohantavirus andesense, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 4.10 |
| Reference: | 10.7554/eLife.81743 |
| Antibody | |
| Antibody: | ANDV-34 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Orthohantavirus andesense glycoprotein N |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >8DBZ_D|Chain B[auth D]|Fv (H) ANDV-34|Homo sapiens (9606) QVHLVQSGGELRKPGSSVKVSCKASGGTFSSFAITWLRQAPGQGLEWVGAYIPVFGSAIHGQKVHGRVTLTADESTTTAYMELSSLRSEDTAVYFCARGPTQNWEYSYYTYFESWGQGTLVTVSS |
Light Chain: E
Mutation: NULL
| >8DBZ_E|Chain C[auth E]|Fv (L) ANDV-34|Homo sapiens (9606) QIVLTQSPGTLSLSPGERATLSCRASQSVTSRYLAWYQQKPGQAPRLLIYDTSSRATGIPDRFSGSGSETDFTLTISRLAPEDFAVYYCQQYGTSPAVTFGQGTRLEIK |
Antigen
Chain: A
Mutation: NULL
| >8DBZ_A|Chain A|Glycoprotein N|Andes orthohantavirus (1980456) TIYELKMECPHTVGLGQGYIIGSTELGLISIEAASDIKLESSCNFDLHTTSMAQKSFTQVEWRKKSDTTDTTNAASTTFEAQTKTVNLRGTCILAPELYDTLKKVKKTVLCYDLTCNQTHCQPTVYLIAPVLTCMSIRSCMASVFTSRIQVIYEKTHCVTGQLIEGQCFNPAHTLTLSQPAHTYDTVTLPISCFFTPKKSEQLKVIKTFEGILTKTGCTENALQGYYVCFLGSHSEPLIVPSLEDIRSAEVVSRMLVHPRGEDHDAIQNSQSHLRIVGPITAKVPSTSSTDTLKGTAFAGVPMYSSLSTLVRNADPEFVFSPGIVPESNHSTCDKKTVPITWTGYLPISGEME |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: VAL54 PHE55 SER57 ALA58 ILE59 HIS60 GLN62 HIS65 GLN102 ASN103 TRP104 GLU105 TYR106 SER107 TYR108 TYR109 E: GLN1 ILE2 GLN27 THR30 SER31 GLU69 GLY93 THR94 SER95 PRO96 A: THR70 MET73 GLN75 LYS76 SER77 PHE78 THR79 THR106 ASN108 ARG110 ALA116 PRO117 GLU118 LYS220 SER221 GLU222 LYS225 THR240 GLU241 ALA243 GLN245 PRO306 SER307 THR308 SER309 SER310 THR311 THR313 ARG333 ASN334 ALA335 ASP336 PRO337 GLU338 ASP355 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
