Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5957 |
| PDBID: | 8DBZ |
| Chains: | BC_A |
| Organism: | Orthohantavirus andesense, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 4.10 |
| Reference: | 10.7554/eLife.81743 |
| Antibody | |
| Antibody: | ANDV-5 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Orthohantavirus andesense glycoprotein N |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >8DBZ_B|Chain D[auth B]|Fv (H) ANDV-5|Homo sapiens (9606) QVQLLQSGAEVKKPGSSVRVSCQSSGDIYNYYGISWVRQAPGQGLEWMGGIIPVYGRPNYVQKFRGRVTFTVDKSTSTAYMELSTLRADDTAVYYCARDTARSHYFGSGNDYGMDVWGQGTTVIVSS |
Light Chain: C
Mutation: NULL
| >8DBZ_C|Chain E[auth C]|Fv (L) ANDV-5|Homo sapiens (9606) DIVMTQSPLSLPVTPGEPASISCRSSQSLLHSNGFNFVDWYLQKPGQSPQLLIYLGSTRASGVPDRFSGSGSGTDFTLEISRVEAEDVGVYYCMQALQFPRTFGQGTKLDIK |
Antigen
Chain: A
Mutation: NULL
| >8DBZ_A|Chain A|Glycoprotein N|Andes orthohantavirus (1980456) TIYELKMECPHTVGLGQGYIIGSTELGLISIEAASDIKLESSCNFDLHTTSMAQKSFTQVEWRKKSDTTDTTNAASTTFEAQTKTVNLRGTCILAPELYDTLKKVKKTVLCYDLTCNQTHCQPTVYLIAPVLTCMSIRSCMASVFTSRIQVIYEKTHCVTGQLIEGQCFNPAHTLTLSQPAHTYDTVTLPISCFFTPKKSEQLKVIKTFEGILTKTGCTENALQGYYVCFLGSHSEPLIVPSLEDIRSAEVVSRMLVHPRGEDHDAIQNSQSHLRIVGPITAKVPSTSSTDTLKGTAFAGVPMYSSLSTLVRNADPEFVFSPGIVPESNHSTCDKKTVPITWTGYLPISGEME |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ASN30 TYR31 TYR32 ILE52 VAL54 TYR55 ARG57 ASN59 ARG65 LYS74 ARG102 HIS104 TYR105 PHE106 GLY107 SER108 ASN110 C: HIS31 SER32 ASN33 A: GLU222 GLN223 LEU224 VAL226 THR229 GLY232 ILE233 LEU234 THR235 TYR247 PRO262 SER263 LEU264 GLU265 ASP266 ILE267 SER269 ALA270 GLU271 VAL273 SER274 LEU277 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
