Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5956 |
| PDBID: | 8DB4 |
| Chains: | GH_F |
| Organism: | Homo sapiens, Arachis hypogaea |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1172/JCI164501 |
| Antibody | |
| Antibody: | 13T1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Arachis hypogaea 2 immunodominant allergen |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >8DB4_G|Chain A, G|13T1 Heavy chain|Homo sapiens (9606) EVQLVESGGGVVQPGGSLRLSCVASGFKFQNYGMSWVRQAPGKGLEWVADISGSDESTYYADSVKGRFTISRDTSKNTLHLQMSSPRAEDTALYYCAKATAPAGKYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTH |
Light Chain: H
Mutation: NULL
| >8DB4_H|Chain B, H|13T1 Light chain|Homo sapiens (9606) EIVMTQSPATLSLSPGEIATLSCRASQTVSSYLAWYQLKPGQAPRLLIYDASRRAAGIPARFSGSESGTDFTLTISSLEPEDSAVYYCHQRSNWPPVHTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: F
Mutation: NULL
| >8DB4_F|Chain E, F|Ara h 2 allergen|Arachis hypogaea (3818) AARRCQSQLERANLRPCEQHLMQKIQRDEDSYERDPYSPSQDPYSPSPYDRRGAGSSQHQERCCNELNEFENNQRCMCEALQQIMENQSDRLQGRQQEQQFKRELRNLPQQCGLRAPQRCDLDVESGGRDRY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: SER52 SER54 ASP55 SER57 TYR59 ALA103 GLY104 LYS105 TYR106 TYR107 TYR109 H: SER30 SER31 TYR32 ASP50 ARG53 ARG91 ASN93 TRP94 F: GLN34 SER35 LEU37 GLU38 ARG39 ALA40 ASN41 LEU42 ARG43 GLU46 GLN111 ILE112 GLU114 ASN115 GLN116 ASP118 ARG119 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
