Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5943 |
| PDBID: | 8D0Y |
| Chains: | DE_B |
| Organism: | Macaca mulatta, Human immunodeficiency virus 1 |
| Method: | XRD |
| Resolution (Å): | 4.70 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 35O22 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 BG505 SOSIPv8 envelope glycoprotein - gp41 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >8D0Y_D|Chain A[auth D]|35O22scFv Heavy Chain Variable|Macaca mulatta (9544) QGQLVQSGATTTKPGSSVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISPYSGDKNLAPAFQDRVNMTTDTEVPVTSFTSTGAAYMEIRNLTSDDTGTYFCAKGLLRDGSSTWLPYLWGQGTLLT |
Light Chain: E
Mutation: NULL
| >8D0Y_E|Chain B[auth E]|35O22scFv Light Chain Variable|Macaca mulatta (9544) VLTQSASVSGSLGQSVTISCTGPNSVCCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSGCVFGTGTKVSVLGQS |
Antigen
Chain: B
Mutation: NULL
| >8D0Y_B|Chain F[auth B]|BG505SOSIPv8 gp41|Human immunodeficiency virus 1 (11676) VFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAPECQQHLLKDTHWGIKQLQARVLAVEHYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLAL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: ARG28 PHE31 TYR32 PHE72 LEU96 LEU97 ARG98 ASP99 E: TYR49 GLU53 ARG54 ALA55 PRO56 B: GLY527 SER528 THR529 ALA532 ARG617 ASN618 SER620 GLU621 ASP624 ASN625 THR627 LEU629 GLN630 LYS633 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
