Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5939 |
| PDBID: | 8CZ8 |
| Chains: | A_E |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.3389/fddsv.2023.1216516 |
| Antibody | |
| Antibody: | anetumab scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human mesothelin |
| Antigen mutation: | No |
| Durg Target: | Q13421; Q13421; |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >8CZ8_A|Chain A, E[auth C]|scFv Anetumab|Homo sapiens (9606) DIALTQPASVSGSPGQSITISCTGTSSDIGGYNSVSWYQQHPGKAPKLMIYGVNNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYDIESATPVFGGGTKLTVLGGGSGGGSGGGSGGGSQVELVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQAPGKGLEWMGIIDPGDSRTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARGQLYGGTYMDGWGQGTLVTVSS |
Antigen
Chain: E
Mutation: NULL
| >8CZ8_E|Chain B[auth E], C[auth M]|Mesothelin, cleaved form|Homo sapiens (9606) GSDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ILE95 GLU96 SER97 ALA98 ARG186 E: SER463 TRP466 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
