Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5854 |
| PDBID: | 8BYU |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.85 |
| Reference: | 10.1016/j.ebiom.2023.104663 |
| Antibody | |
| Antibody: | HexaBody-CD38 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Erzotabart(Phase-I/II) |
| Antigen | |
| Antigen: | Human CD38 |
| Antigen mutation: | No |
| Durg Target: | P28907 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8BYU_H|Chain A[auth H]|Fab Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCKAFGGTFSSYAISWVRQAPGQGLEWMGRIIRFLGIANYAQKFQGRVTLIADKSTNTAYMELSSLRSEDTAVYYCAGEPGERDPDAVDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTHHHHHH |
Light Chain: L
Mutation: NULL
| >8BYU_L|Chain B[auth L]|Fab Light Chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQGIRSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >8BYU_A|Chain C[auth A]|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1|Homo sapiens (9606) HHHHHHRWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFATSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: THR28 PHE29 SER30 SER31 TYR32 ILE52 ARG53 PHE54 LEU55 ILE57 LYS74 THR76 PRO100 GLY101 GLU102 ARG103 ASP104 L: ARG30 SER31 TRP32 SER67 A: GLU72 ILE73 HIS74 PRO75 GLU76 ARG78 HIS79 THR116 VAL117 PRO118 CYS119 ASN120 LYS121 ARG140 ASP141 PHE143 CYS201 ASP202 GLU233 LYS234 GLN236 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
