Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5850 |
| PDBID: | 8BLQ |
| Chains: | AB_D |
| Organism: | Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.97 |
| Reference: | 10.1038/s41598-023-35678-4 |
| Antibody | |
| Antibody: | CODV Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human interleukin-13 |
| Antigen mutation: | No |
| Durg Target: | P35225; P35225; |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >8BLQ_A|Chain A|CODV-Fab, heavy chain|Homo sapiens (9606) VQLQQSGPELVKPGASVKISCKASGYSFTSYWIHWIKQRPGQGLEWIGMIDPSDGETRLNQRFQGRATLTVDESTSTAYMQLRSPTSEDSAVYYCTRLKEYGNYDSFYFDVWGAGTLVTVSSGEVQLKESGPGLVAPGGSLSITCTVSGFSLTDSSINWVRQPPGKGLEWLGMIWGDGRIDYADALKSRLSISKDSSKSQVFLEMTSLRTDDTATYYCARDGYFPYAMDFWGQGTSVTVSSGGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
Light Chain: B
Mutation: NULL
| >8BLQ_B|Chain B|CODV-Fab, light chain|Homo sapiens (9606) DIVLTQSPASLAVSLGQRATISCRASESVDSYGQSYMHWYQQKAGQPPKLLIYLASNLESGVPARFSGSGSRTDFTLTIDPVQAEDAATYYCQQNAEDSRTFGGGTKLEIKGGGGGGGDIQMTQSPASLSVSVGDTITLTCHASQNIDVWLSWFQQKPGNIPKLLIYKASNLHTGVPSRFSGSGSGTGFTLTISSLQPEDIATYYCQQAHSYPFTFGGGTKLEIKGGGGGRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR |
Antigen
Chain: D
Mutation: NULL
| >8BLQ_D|Chain D|Interleukin-13, human|Homo sapiens (9606) PPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGQFN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR154 ASP155 SER156 SER157 TRP176 GLY177 ASP178 ARG180 ASP222 GLY223 TYR224 PHE225 TYR227 B: SER31 TYR32 GLY33 GLN34 TYR36 TYR53 LEU54 ASN57 ASN95 ALA96 GLU97 D: GLU30 ALA44 PRO45 CYS47 ASN48 SER50 LEU66 ILE70 ASN71 VAL72 SER73 GLY74 CYS75 SER76 ALA77 GLU79 LYS80 GLN82 ARG83 MET84 SER86 GLY87 LYS92 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
