Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 583 |
| PDBID: | 3LQA |
| Chains: | HL_G |
| Organism: | Homo sapiens, Human immunodeficiency virus 1 |
| Method: | XRD |
| Resolution (Å): | 3.40 |
| Reference: | 10.1038/nsmb.1796 |
| Antibody | |
| Antibody: | S4 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 clade C gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3LQA_H|Chain C[auth H]|Heavy chain of anti HIV Fab from human 21c antibody|Homo sapiens (9606) QVQVVQSGAEVRKPGASVKVSCKVSGFTLTGLSIHWVRQAPGKGLEWMGGFGPEENEIIYAQKFQGRVSMTEDTSTNTAYMELSSLRSEDTAVYYCATGGNYYNLWTGYYPLAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKT |
Light Chain: L
Mutation: NULL
| >3LQA_L|Chain D[auth L]|Light chain of anti HIV Fab from human 21c antibody|Homo sapiens (9606) QSVLTQPPSVSAAPGQKVTISCSGSSSNIGKNYVSWYQQLPGAAPKLLIFDDTQRPSGIPDRFSGSKSGTSATLAITGLQTGDEADYYCGTWDSSLSTGQLFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTMAHAECS |
Antigen
Chain: G
Mutation: NULL
| >3LQA_G|Chain B[auth G]|Envelope glycoprotein gp160|HIV-1 (11676) EIVLENVIENFNMWKNDMVDQMHQDIISLWDQSLKPCVKLTPLCVGAGNCNTSTIAQACPKVSFDPIPIHYCAPAGYAILKCNDKTFNGIGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEEEVVIRSENISNNVKTIIVHLTESVNITCIGAGHCNINEKAWNETLKKVVEKLVKYFPNKTIEFAPPVGGDLEITTHSFNCGGEFFYCNTTKLFNSIHNSTDSTVNSTDSTAETGNSTNTNITLPCRIRQIINMWQEVGRAMYAPPSKGNITCISDITGLLLTRDGGENKTENNDTEIFRPGGGDMKDNWRSELYKYKVVEIKSGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR28 THR30 GLY31 LEU32 PHE51 PRO53 GLU54 GLU55 ASN56 THR74 SER75 TYR102 TYR103 ASN104 LEU105 TRP106 THR107 GLY108 G: CYS118 VAL119 LEU121 THR122 PRO123 ASN193 THR194 THR196 ALA198 GLN199 ALA200 LEU363 GLU364 ARG418 ILE419 ARG420 GLN421 ILE422 ILE423 ASN424 VAL429 GLY430 ARG431 MET433 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
