Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5823 |
| PDBID: | 8AHN |
| Chains: | HL_A |
| Organism: | Orthohantavirus sinnombreense, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.80 |
| Reference: | 10.1038/s41564-023-01413-y |
| Antibody | |
| Antibody: | SNV-42 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Orthohantavirus sinnombreense virus envelope polyprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8AHN_H|Chain C[auth H]|Fab SNV-42 heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTFSTYEMNWVRQAPGKGLEWISYIRSSGSTVYYADSVKGRFTISRDNAKNLLYLQMNSLRAGDTAVYYCARIPGGYTGYFDYWGQGALVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >8AHN_L|Chain B[auth L]|Fab SNV-42 light chain|Homo sapiens (9606) QSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYYVHWYQQLPGTVPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQTEDEADYYCQSYDSSLSGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >8AHN_A|Chain A|Envelope polyprotein|Sin Nombre orthohantavirus (3052499) RNLYELKIECPHTVGLGQGYVTGSVETTPILLTQVADLKIESSCNFDLHVPATTTQKYNQVDWTKGGSGFEAKTKEVNLKGTCNIPPTTFEAAYKSRKTVICYDLACNQTHCLPTVHLIAPVQTCMSVRSCMIGLLSSRIQVIYEKTYCVTGQLIEGLCFIPTHTIALTQPGHTYDTMTLPVTCFLVAKKLGTQLKLAVELEKLITGVSCTENSFQGYYICFIGKHSEPLFVPTMEDYRSAELFTRMVLNPRGEDHDPDQNGQGLMRIAGPVTAKVPSTETTETMQGIAFAGAPMYSSFSTLVRKADPEYVFSPGIIAESNHSVCDKKTVPLTWTGFLAVSGEIERIGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR36 TYR37 TYR54 ASN65 ARG66 PRO67 SER68 TYR103 TRP110 H: THR35 TYR36 GLU37 TYR54 ARG56 SER57 SER58 SER62 TYR65 ARG104 ILE105 PRO106 GLY107 GLY108 TYR109 THR110 GLY111 TYR112 A: SER88 ALA102 THR241 GLU242 SER244 PRO301 THR303 ALA304 LYS305 THR309 GLU310 THR311 THR312 GLU313 THR314 GLN316 ARG334 LYS335 ASP356 LYS357 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
