Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5780 |
| PDBID: | 7ZLK |
| Chains: | ST_C |
| Organism: | Human immunodeficiency virus 1, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.99 |
| Reference: | 10.1371/journal.ppat.1010945 |
| Antibody | |
| Antibody: | ACS122 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 AMC009 SOSIPv5.2 envelope glycoprotein - gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: S
Mutation: NULL
| >7ZLK_S|Chain I[auth M], O[auth S]|ACS122 heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSEALSLTCSVSGVAISRHYWNWIRQPPGKGLEWIGYIFFNGNTNYSPSLKSRVTISVDTSKNEFSLTLRSVTAADTAVYYCAREKSVVEPDNMVRWFDPWGQGTLVTVSS |
Light Chain: T
Mutation: NULL
| >7ZLK_T|Chain J[auth N], P[auth T]|ACS122 light chain|Homo sapiens (9606) SYELTQPPSVSVAPGKTARITCGGNNIGSKSVHWYQQKPGQAPVLVIYYDSDRPSGIPERFSGSKSGNTATLTISRVEAGDEADYYCQVWDSSRDHCVFGIGTKVTVL |
Antigen
Chain: C
Mutation: NULL
| >7ZLK_C|Chain A, C, E[auth D]|AMC009 SOSIPv5.2 envelope glycoprotein gp120|Human immunodeficiency virus 1 (11676) ARADKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVRNVWATHCCVPTDPNPQEVVLENVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDYVGNATNASTTNATGGIGGTVERGEIKNCSFNITTSIRDKVQKEYALFYKLDIVPIDNDNTNNSYRLINCNTSVIKQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEKEVVIRSQNFTNNAKVIIVQLNESVVINCTRPNNNTRKSIHIAPGRWFYTTGAIIGDIRQAHCNISRVKWNNTLKQIATKLREQFKNKTIAFNQSSGGDPEIVMHSFNCGGEFFYCNTTQLFNSTWNDTEVSNYNDITHITLPCRIKQIINMWQKVGKAMYAPPIRGQIRCSSNITGLLLTRDGGSNENKTSETETFRPAGGDMRDNWRSELYKYKVVKIEPLGVAPTKCKRRVVQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| S: ALA28 SER30 ARG31 PHE53 THR73 VAL98 VAL99 T: TYR48 ASP49 SER50 ASP51 C: THR37 TYR39 GLU87 ASN88 PRO498 THR499 LYS500 CYS501 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
