Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5778 |
| PDBID: | 7ZLK |
| Chains: | HL_D |
| Organism: | Human immunodeficiency virus 1, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.99 |
| Reference: | 10.1371/journal.ppat.1010945 |
| Antibody | |
| Antibody: | ACS114 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 AMC009 SOSIPv5.2 envelope glycoprotein - gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7ZLK_H|Chain G[auth H], K[auth O], M[auth Q]|ACS114 heavy chain|Homo sapiens (9606) QVQLQQWGGGLLKPSQTLSLTCAVYRWTFNDHYWSWVRQSPGKGLEWIGEISWGGATNYNPSLKSRVTMSVDTSMSHVSLKMTSVTAADTGVYYCVRVGPGPHMAALDYWGHGSRVLVSS |
Light Chain: L
Mutation: NULL
| >7ZLK_L|Chain H[auth L], L[auth P], N[auth R]|ACS114 light chain|Homo sapiens (9606) DIVMTQTPLSSPVTLGQPASISCGSSQSLVHSDGNTYLSWLQQRPGQPPRLLIYKISNRISGLPDRFSGSGAETNFTLKISRVEAEDVGLYYCVQGTQFPWTSGQGTKVEIK |
Antigen
Chain: D
Mutation: NULL
| >7ZLK_D|Chain A, C, E[auth D]|AMC009 SOSIPv5.2 envelope glycoprotein gp120|Human immunodeficiency virus 1 (11676) ARADKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVRNVWATHCCVPTDPNPQEVVLENVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDYVGNATNASTTNATGGIGGTVERGEIKNCSFNITTSIRDKVQKEYALFYKLDIVPIDNDNTNNSYRLINCNTSVIKQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEKEVVIRSQNFTNNAKVIIVQLNESVVINCTRPNNNTRKSIHIAPGRWFYTTGAIIGDIRQAHCNISRVKWNNTLKQIATKLREQFKNKTIAFNQSSGGDPEIVMHSFNCGGEFFYCNTTQLFNSTWNDTEVSNYNDITHITLPCRIKQIINMWQKVGKAMYAPPIRGQIRCSSNITGLLLTRDGGSNENKTSETETFRPAGGDMRDNWRSELYKYKVVKIEPLGVAPTKCKRRVVQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR25 ARG26 TRP27 THR28 ASN30 ASP31 TRP53 ASP72 THR73 SER74 MET75 SER76 D: ASN295 THR297 PRO299 ASN301 ASN332 ILE439 ARG440 GLY441 GLN442 ILE443 ARG444 CYS445 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
