Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 571 |
| PDBID: | 3L5X |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1016/j.jmb.2010.03.004 |
| Antibody | |
| Antibody: | H2L6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-13 |
| Antigen mutation: | No |
| Durg Target: | P35225 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3L5X_H|Chain B[auth H]|H2L6 HEAVY CHAIN|Homo sapiens (9606) QVTLKESGPVLVKPTETLTLTCTVSGFSLSTYGMGVGWIRQPPGKALEWLAHIWWDDVKRYNPALKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARMGSDYDVWFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >3L5X_L|Chain A[auth L]|H2L6 LIGHT CHAIN|Homo sapiens (9606) EIVLTQSPATLSLSPGERATLSCRASKSISKYLAWYQQKPGQAPRLLIYSGSTLQSGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQHNEYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >3L5X_A|Chain C[auth A]|Interleukin-13|Homo sapiens (9606) MGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: LYS31 TYR32 HIS91 ASN92 TYR96 H: TYR32 TRP54 TRP55 ASP56 VAL58 ARG60 ASP103 TYR104 ASP105 VAL106 A: ARG11 ILE14 GLU15 VAL18 LEU101 LYS104 LYS105 PHE107 ARG108 GLU109 GLY110 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
