Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5707 |
| PDBID: | 7Z2M |
| Chains: | HL_I |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1038/s42003-023-05369-x |
| Antibody | |
| Antibody: | 11.003 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human Interleukin-17A |
| Antigen mutation: | Yes |
| Durg Target: | Q16552 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7Z2M_H|Chain B, D, F, H|11.003 Fab heavy-chain|Homo sapiens (9606) EVQLVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWMGIIYPSDSDTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARYPNYGAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH |
Light Chain: L
Mutation: NULL
| >7Z2M_L|Chain A, C, E, L|11.003 Fab light-chain|Homo sapiens (9606) EIVLTQSPATLSLSPGERATLSCRASQSVFSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYFYWGWPFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: I
Mutation: C96S
| >7Z2M_I|Chain G, I, J, K|Interleukin-17A|Homo sapiens (9606) PNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHSPNSFRLEKILVSVGCTCVTPIVHHVA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER28 THR30 SER31 TRP33 ILE50 TYR52 SER54 ASP55 ASP57 ARG59 LYS74 TYR99 ASN101 TYR102 L: GLU1 ILE2 GLN27 SER28 PHE30 TYR32 PHE92 TYR93 TRP94 I: ASN52 LEU53 HIS54 ARG55 ASN56 GLU57 ASP58 PRO59 ARG61 GLU68 ALA69 LYS70 CYS71 ARG72 HIS73 LEU74 TYR85 ASN88 SER89 VAL90 PRO91 GLN93 SER118 VAL124 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
