Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5697 |
| PDBID: | 7YRU |
| Chains: | HL_A |
| Organism: | Homo sapiens, Rattus norvegicus |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1038/s41467-023-38746-5 |
| Antibody | |
| Antibody: | Rm0443 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human activin receptor-like kinase 2 (ALK2) |
| Antigen mutation: | No |
| Durg Target: | Q04771 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7YRU_H|Chain B[auth H]|antibody heavy chain|Rattus norvegicus (10116) EVQLVESGGGLVQPGRSLKLSCLASGSTFSNYGMKWIRQAPGKGLEWVASISRSSTYIYYADTVKGRFTISRDNARNTLYLQMTSLRSEDTALYYCAAAISTPFYWYFDFWGPGTVVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTH |
Light Chain: L
Mutation: NULL
| >7YRU_L|Chain C[auth L]|antibody light chain|Rattus norvegicus (10116) EIVLTQSPTTMAASPGEKVTLNCLASSSVSYMTWYQQKSGASPKLWIYGTSNLASGVPNRFSGSGSGTSYSLAISSMEAEDVATYYCLHLTSYPPYTFGAGTKLELKRAVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7YRU_A|Chain A|Activin receptor type-1|Homo sapiens (9606) MEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASN31 TYR32 GLY33 LYS35 SER50 ILE51 SER52 ARG53 SER54 THR56 TYR57 TYR59 ALA99 SER101 THR102 PRO103 PHE104 TYR105 TRP106 L: GLU1 SER27 SER28 VAL29 SER30 TYR31 LEU90 THR91 SER92 TYR93 TYR96 A: GLU38 GLY39 ILE59 ASN60 ASP61 GLY62 PHE63 HIS64 VAL65 TYR66 LYS68 GLY88 ARG101 ASN102 THR104 ALA105 GLN106 LEU107 PRO108 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
