Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5695 |
| PDBID: | 7YRF |
| Chains: | FE_C |
| Organism: | Coxsackievirus A16, Mus musculus |
| Method: | EM |
| Resolution (Å): | 2.91 |
| Reference: | 10.1038/s41467-022-35575-w |
| Antibody | |
| Antibody: | 8C4 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Coxsackievirus A16 capsids glycoprotein VP3 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: F
Mutation: NULL
| >7YRF_F|Chain D[auth F]|The heavy chain of the antibody 8C4|Mus musculus (10090) QVQLQQSGPELVKPGASVKISCKASGYAFSTSWMNWVIQRPGQGLEWIGRIYPGDGDTNYNGKFKGKATLTADKSSSTAYMQLSSLTSVDSAVYFCARRDYGYFDYWGQGTTLTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKL |
Light Chain: E
Mutation: NULL
| >7YRF_E|Chain B[auth E]|Light chain of chain|Mus musculus (10090) DIQMTQSSSYLSVSLGGRVTITCKASDHINNWLAWYQQKPGNAPRLLISGATSLETGVPSRFSGSGSGKDYTLSITSLQTEDVATYYCQQYWNSPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: C
Mutation: NULL
| >7YRF_C|Chain E[auth C]|Capsid protein VP3|Coxsackievirus A16 (31704) GIPTELKPGTNQFLTTDDGVSAPILPGFHPTPPIHIPGEVRNLLEICRVETILEVNNLKTNETTPMQRLCFPVSVQSKTGELCAAFRADPGRDGPWQSTILGQLCRYYTQWSGSLEVTFMFAGSFMATGKMLIAYTPPGGSVPADRITAMLGTHVIWDFGLQSSVTLVVPWISNTHYRAHARAGYFDYYTTGIITIWYQTNYVVPIGAPTTAYIVALAAAQDNFTMKLCKDTEDIEQTANIQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: ASN30 TRP32 TYR91 TRP92 F: ARG99 ASP100 TYR101 C: VAL75 SER77 LYS78 VAL204 THR210 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
