Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 569 |
| PDBID: | 3L5W |
| Chains: | HL_I |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1016/j.jmb.2010.03.004 |
| Antibody | |
| Antibody: | C836 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-13 |
| Antigen mutation: | No |
| Durg Target: | P35225 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3L5W_H|Chain B, E[auth H]|C836 HEAVY CHAIN|Mus musculus (10090) QVTLKESGPGILQPSQTLSLTCSFSGFSLSTYGMGVGWIRQPSGKGLEWLAHIWWDDVKRYNPALKSRLTISKDTSGSQVFLKIASVDTSDTATYYCARMGSDYDVWFDYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH |
Light Chain: L
Mutation: NULL
| >3L5W_L|Chain A, D[auth L]|C836 LIGHT CHAIN|Mus musculus (10090) DVQITQSPSYLAASPGETITLNCRASKSISKYLAWYQEKPGKTNKLLIYSGSTLQSGIPSRFSGSGSGTDFTLTISSLEPEDFAMYFCQQHNEYPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: I
Mutation: NULL
| >3L5W_I|Chain C[auth I], F[auth J]|Interleukin-13|Homo sapiens (9606) MGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER30 LYS31 TYR32 HIS91 ASN92 TYR96 H: TYR32 TRP54 TRP55 ASP56 VAL58 ARG60 ASP103 TYR104 ASP105 VAL106 I: THR8 ARG11 GLU12 ILE14 GLU15 VAL18 LEU101 LYS104 LYS105 PHE107 ARG108 GLU109 GLY110 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
