Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5643 |
| PDBID: | 7XY8 |
| Chains: | IM_B |
| Organism: | Homo sapiens, synthetic construct |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1155/2022/3552793 |
| Antibody | |
| Antibody: | h4#147D Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human CD147 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >7XY8_I|Chain C[auth H], D[auth I]|heavy chain|synthetic construct (32630) QVQLVQSGAEVKKPGASVKVSCKASGYTFTSDFMHWVRQAPGQGLEWMGWIYPGDGDTEYNQKFQGRVTLTRDTSISTAYMELSRLRSDDTAVYYCARGRGYVMDAWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPS |
Light Chain: M
Mutation: NULL
| >7XY8_M|Chain E[auth L], F[auth M]|light chain|synthetic construct (32630) DIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAIKPLIYYTSNLQSGVPSRFSGSGSGTDYTLTISSLQPEDFATYFCQQYDSSPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >7XY8_B|Chain A, B|Isoform 2 of Basigin|Homo sapiens (9606) MGSSHHHHHHSSGENLYFQGSAAGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: THR28 THR30 SER31 ASP32 PHE33 HIS35 TRP50 TYR52 ASP55 ASP57 THR58 GLU59 GLY99 ARG100 GLY101 TYR102 M: TYR32 TYR50 TYR91 ASP92 SER93 SER94 ARG96 B: ARG106 LYS108 ALA109 VAL110 LYS111 LYS127 SER128 GLU129 SER130 VAL131 PRO132 PRO133 VAL134 THR135 GLN164 GLY165 ARG166 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
