Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5610 |
| PDBID: | 7XJF |
| Chains: | AB_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.7150/thno.79367 |
| Antibody | |
| Antibody: | 6MW3211 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human leukocyte surface antigen CD47 |
| Antigen mutation: | Yes |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7XJF_A|Chain A|Heavy chain of 6MW3211 Fab|Homo sapiens (9606) EVQLVQSGAEVKKPGASVKVSCKASGYKFTNYVMSWVRQAPGQRLEWMGYINPYNDAIKYNEKFTGRVTITRDTSASTAYMELSSLRSEDTAVYYCAREGDFYANYGRLGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: B
Mutation: NULL
| >7XJF_B|Chain B|Light chain of 6MW3211 Fab|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLLYYTSRLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYFCQQGAGFPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: C15G
| >7XJF_C|Chain C|Leukocyte surface antigen CD47|Homo sapiens (9606) QLLFNKTKSVEFTFGNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR30 ASN31 TYR32 VAL33 ASN52 TYR54 ASN55 ASP101 PHE102 TYR103 ALA104 LEU109 B: TYR32 TYR49 TYR50 ARG53 C: GLN1 ASN32 THR34 GLU35 VAL36 TYR37 ASP51 ALA53 LEU54 LYS56 THR99 LEU101 THR102 ARG103 GLU104 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
