Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5573 |
| PDBID: | 7X7V |
| Chains: | CD_E |
| Organism: | Mus musculus, Severe acute respiratory syndrome-related coronavirus |
| Method: | EM |
| Resolution (Å): | 3.83 |
| Reference: | 10.1073/pnas.2204256119 |
| Antibody | |
| Antibody: | X01 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >7X7V_C|Chain F[auth C]|X01 heavy chain|Mus musculus (10090) EIQLQQSGPELVAPGASVKVSCKASGYAFTSYNMYWVRQSHGKSLEWIGYIVPYNGGTTYNQEFKGKATLTVDKSSNTAYIHLNSLTSEDSAVYYCAKEGTYYGYDGVLADWGQGTLVT |
Light Chain: D
Mutation: NULL
| >7X7V_D|Chain E[auth D]|X01 light chain|Mus musculus (10090) DIQMTQSSSYLSVSLGGRVTITCKASDHINNWLAWYQQKPGNAPRLLISGVTNLETGVPSRFSGSGSGKNFTLSIASLQTEDVATYYCQQYWSFPWTFGGGTKLEIR |
Antigen
Chain: E
Mutation: NULL
| >7X7V_E|Chain G[auth E]|Spike protein S1|Severe acute respiratory syndrome coronavirus (694009) TNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition D: ASN30 ASN31 TRP32 GLY50 VAL51 THR52 ASN53 THR56 TYR91 TRP92 SER93 C: THR30 SER31 TYR32 ASN33 VAL52 TYR54 GLU99 GLY100 THR101 TYR102 TYR103 GLY104 TYR105 ASP106 E: TYR356 ASN357 SER358 THR359 PHE361 SER362 THR363 PHE364 LYS365 CYS366 TYR367 ALA371 THR372 GLY391 ASP392 VAL394 ARG395 PRO399 GLY400 GLN401 THR402 ASP414 ILE489 GLY490 TYR494 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
