Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5572 |
| PDBID: | 7X7U |
| Chains: | AB_G |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.77 |
| Reference: | 10.1073/pnas.2204256119 |
| Antibody | |
| Antibody: | X17 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Delta spike glycoprotein RBD |
| Antigen mutation: | Yes |
| Durg Target: | P0DTC2; P0DTC2; P0DTC2; |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7X7U_A|Chain E[auth A]|X17 heavy chain|Mus musculus (10090) QVQLQQSGAELARPGASVKLSCKASGYTFTFYWMQWLKQRPGQGLEWIGAIYPGDGDTRYTQRFKDKATLTADKSSSTAYIQLSSLASEDSAVYYCAGGEYDNYGFDYWGQGTTLTVSS |
Light Chain: B
Mutation: NULL
| >7X7U_B|Chain D[auth B]|X17 light chain|Mus musculus (10090) DIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGTTLPYTFGGGTKLEIK |
Antigen
Chain: G
Mutation: L129R/T155K
| >7X7U_G|Chain A[auth G]|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) ESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: TYR32 TYR50 LEU54 SER56 GLY91 THR92 THR93 LEU94 TYR96 A: TYR27 THR28 PHE31 TYR32 TRP33 TYR52 ASP55 ASP57 ARG59 GLU100 TYR101 ASP102 ASN103 TYR104 ASP107 TYR108 G: TRP353 ASN354 ARG355 ARG357 SER359 ASN360 THR393 ASN394 TYR396 PRO426 ASP427 ASP428 PHE429 LYS462 PRO463 PHE464 GLU465 ARG466 ILE468 SER514 GLU516 LEU518 HIS519 ALA520 PRO521 THR523 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
