Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5571 |
| PDBID: | 7X7U |
| Chains: | HL_G |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.77 |
| Reference: | 10.1073/pnas.2204256119 |
| Antibody | |
| Antibody: | X10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Delta spike glycoprotein RBD |
| Antigen mutation: | Yes |
| Durg Target: | P0DTC2; P0DTC2; P0DTC2; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7X7U_H|Chain C[auth H]|X10 heavy chain|Mus musculus (10090) EVQLQQSGPELVKPGASVKISCKTSGYTFTEYTLHWVKQSHGKSLEWIGGFDPNFGGATYNLKFEDKATLTVDKSSNTAYMELRSLTSEDSAVFYCARGDYGTSYAYFDFWGQGTTLTVSS |
Light Chain: L
Mutation: NULL
| >7X7U_L|Chain B[auth L]|X10 light chain|Mus musculus (10090) DIVLTQSPASLAVSLGQRAAISCRASQSVSTSSHNYVHWYQQRPGQPPKLLIKYASNLECGVPARFSGSGSGTDFTLNIHPVEEEDSAAYYCQHSWEIPYTFGGGTKLEIK |
Antigen
Chain: G
Mutation: L129R/T155K
| >7X7U_G|Chain A[auth G]|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) ESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition L: GLN27 SER28 SER30 THR31 SER32 SER33 HIS34 TYR36 TYR54 SER71 GLY72 THR73 SER95 TRP96 GLU97 ILE98 TYR100 H: ASP52 ASN54 PHE55 GLY57 ALA58 THR59 ASP100 TYR101 GLY102 THR103 SER104 TYR105 ALA106 TYR107 G: ASN343 ALA344 THR345 ARG346 TYR351 ALA352 ASN440 LEU441 ASP442 SER443 LYS444 GLY447 ASN448 TYR449 ASN450 TYR451 ARG452 LEU455 ILE468 THR470 GLU471 ILE472 VAL483 GLU484 TYR489 PHE490 LEU492 GLN493 SER494 ARG509 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
